Revel's CMLase Cuts 75-Year-Old Skin AGEs to 31-Year-Old Levels
Updated
Updated · The Independent · Jul 24
Revel's CMLase Cuts 75-Year-Old Skin AGEs to 31-Year-Old Levels
3 articles · Updated · The Independent · Jul 24
Summary
Laboratory tests on donated human skin and arterial tissue showed Revel Pharmaceuticals' CMLase enzyme reduced AGE damage in 75-year-old skin to levels seen in 31-year-old tissue.
The enzyme targets advanced glycation end products—aging-linked compounds that build up in tissue, drive inflammation and stiffness, and raise vulnerability to disease and injury.
Using AI, researchers screened DNA from more than 50,000 microbes to identify enzyme candidates capable of clearing AGEs from human tissue.
Revel says the findings mark structural reversal of AGE-related damage in human tissue under lab conditions, with future studies planned in inflammatory eye diseases, including diabetes-related disorders.