LASSS More Than Doubles HGF Binding, Blocking 5-Day Muscle Atrophy Nitration
Updated
Updated · Nature.com · Jul 24
LASSS More Than Doubles HGF Binding, Blocking 5-Day Muscle Atrophy Nitration
3 articles · Updated · Nature.com · Jul 24
Summary
A 1:8000 LASSS-to-HGF treatment more than doubled HGF’s binding to the c-met receptor after washout of free compound, indicating a direct HGF-enhancing effect rather than a transient antioxidant action.
The same treatment made HGF resistant to peroxynitrite-driven nitration—especially at Y198—while preserving satellite-cell activation; glutathione trisulfide and ordinary lipoic acid did not boost binding or match that protection.
In mice, 3 days of oral LASSS pre-administration at about 50 μg/g per day prevented the rise in extracellular HGF nitration during 5 days of tail-suspension-induced muscle disuse, whereas GSSSG failed in vivo.
The study links LASSS to a possible chemical remodeling of HGF that could help counter age-related muscle atrophy, sarcopenia and impaired regeneration, though therapeutic benefit in aging animals or humans remains unproven.
If standard lipoic acid supplements fail to protect muscle repair, how soon could this specialized compound become available to combat human aging?
Could transforming a natural healing protein into a supercharged version unintentionally trigger dangerous cell growth instead of just repairing aging muscles?