Italian Study Links 4-6 Daily Coffees to 59% Lower MASLD Odds

1 articles · Updated · Daily Coffee News · Aug 5

1,079 adults in southern Italy who drank espresso or moka coffee daily showed lower odds of MASLD, with the apparent benefit strengthening cup by cup and leveling off at 4-6 cups a day.
One cup was linked to about 52% lower odds versus less than one cup daily, rising to 53% at two cups, 55% at three and 59% at 4-6 cups after adjustment for diet, BMI, smoking and other factors.
Espresso and moka brews may differ from filtered or instant coffee because pressure-based extraction without paper filters retains more diterpenes and chlorogenic acids, compounds tied to antioxidant and anti-inflammatory effects.
The authors said the findings support viewing Italian-style coffee as a possible functional food for MASLD prevention, but the observational design, self-reported diet data and missing physical-activity data limit causal claims.
The study adds brewing-method detail to broader evidence linking coffee to liver health, including a 2025 review and a 2021 UK Biobank analysis showing lower chronic liver disease risk among coffee drinkers.