Study Links High Glucose to Cancer Immune Evasion, Flags HSF1 as Drug Target
Sanford Burnham Prebys Identifies HSF1 Target for Cancer Immune EvasionInside Precision Medicine13d ago Scientists Identify HSF1 Protein as Cancer Therapeutic Target to Disrupt Protective LayerHigh glucose thickens cancer cells' sugar shield, helping them evade immune attackStripping away what conceals cancer cells from our immune system - Sanford Burnham PrebysHow Fibroblasts Become Tumor-Promoting CAFsπ βTissue-resident fibroblasts are activated by stress signals, hypoxia, and pathways such as TGF-Ξ², NOTCH, PDGF, IL-1, ROS, YAP1, and HSF1. Once activated, they transform into diverse cancer-associatedSanford Burnham Prebys Scientists Discover How to Thin Cancer Cells' Sugary ShroudSanford Burnham Prebys Identifies Protein Inhibiting Cancer Cell Cloaking