45-Year-Old Resumes Testosterone After Psychosis, 2-Month Follow-Up Shows No Relapse
Updated
Updated · Gizmodo · Aug 18
45-Year-Old Resumes Testosterone After Psychosis, 2-Month Follow-Up Shows No Relapse
3 articles · Updated · Gizmodo · Aug 18
Summary
Two months after discharge, the 45-year-old showed no relapse of psychosis, allowing doctors to taper his psychiatric drugs and restart testosterone under close monitoring.
A year into monthly testosterone therapy, he developed hallucinations, paranoia and manic behavior; symptoms improved within days after doctors stopped the hormone and started antipsychotics.
Doctors later found he had Klinefelter syndrome—an XXY condition linked to low testosterone and higher psychiatric risk—and said injection-driven hormone peaks and troughs likely disrupted dopamine pathways.
The case report says psychiatric complications from therapeutic testosterone are underrecognized and urges baseline mental-health screening, vigilant monitoring and prompt discontinuation if symptoms emerge.