Australian Study Links Annexin A1 to Worse Hypertension Damage in Females, With 1.4 Billion Affected
Updated
Updated · AL DÍA News · Aug 18
Australian Study Links Annexin A1 to Worse Hypertension Damage in Females, With 1.4 Billion Affected
1 articles · Updated · AL DÍA News · Aug 18
Summary
Australian researchers found hypertensive mice lacking annexin A1 developed more severe aortic and heart damage, with the effect strongest in females.
ANXA1 helps resolve inflammation, and its absence was also tied to changes in mitochondrial-related proteins and function, suggesting a pathway by which high blood pressure drives organ injury.
Estrogen appeared to raise ANXA1 levels, pointing to a possible estrogen-ANXA1 mechanism that may help protect female cardiovascular tissue from hypertension-related remodeling.
The study, published in Communications Biology, was conducted in animals and does not show that boosting ANXA1 lowers blood pressure or treats hypertension in humans.
WHO estimates 1.4 billion adults aged 30 to 79 had hypertension in 2024, with only about 23% under control, underscoring interest in damage-limiting approaches beyond pressure reduction.