8 p.m. ET marks the start of the six-fight main card on Paramount+ after a seven-fight preliminary slate begins at 5 p.m. ET on the same platform.
Hernandez enters at 15-3 with 1 no contest, trying to rebound from a February loss to Sean Strickland that ended his eight-fight winning streak.
Rodrigues, 19-6, arrives on a three-fight run and has finished seven of his 10 UFC wins by knockout, giving the bout added stakes in the middleweight picture.