Omega-3 Plus Low-Dose Aspirin Matches Antibiotics in 109-Patient Gum Disease Trial
Updated
Updated · SciTechDaily · Aug 21
Omega-3 Plus Low-Dose Aspirin Matches Antibiotics in 109-Patient Gum Disease Trial
1 articles · Updated · SciTechDaily · Aug 21
Summary
A 109-patient randomized trial found omega-3 plus low-dose aspirin delivered nearly the same one-year results as metronidazole and amoxicillin for severe periodontitis when added to standard deep cleaning.
After 12 months, 57.7% of patients on omega-3 and aspirin reached the target of four or fewer deep periodontal pockets, versus 58% with antibiotics and 23.1% with placebo; combining both therapies added no benefit.
Researchers said the regimen may work by modulating inflammation rather than directly killing bacteria, potentially offering an option for patients who cannot take antibiotics and helping curb resistance risks.
The benefit persisted six months after supplementation ended, but the authors said routine replacement of antibiotics is premature because participants were otherwise healthy and broader studies are still needed.