UW-Madison Review of 350 Studies Says Less Protein May Extend Sedentary Adults' Lifespan
Updated
Updated · Labmate Online · Aug 21
UW-Madison Review of 350 Studies Says Less Protein May Extend Sedentary Adults' Lifespan
1 articles · Updated · Labmate Online · Aug 21
Summary
More than 350 studies reviewed by University of Wisconsin-Madison researchers found that cutting protein intake may slow ageing, lower age-related disease risk and in some cases extend lifespan in physically inactive adults.
FGF21 emerged as a key mechanism: low protein intake raises the hormone, which has been linked to higher energy expenditure, better blood-sugar control and less inflammation in animals and humans.
The review also flagged methionine, isoleucine and valine as amino acids that may drive harmful growth-related pathways when consumed in excess, increasing risks tied to obesity and inflammation.
The findings push against this year's US guidance lifting recommended protein intake to 1.2-1.6 grams per kilogram, with the authors arguing protein advice should be personalized by physical activity, not age alone.