Japanese Study Finds Pterostilbene Cuts Fat in Mouse Muscle Cells, Preserving PPAR-delta
Updated
Updated · Fox News · Sep 12
Japanese Study Finds Pterostilbene Cuts Fat in Mouse Muscle Cells, Preserving PPAR-delta
3 articles · Updated · Fox News · Sep 12
Summary
Sept. 1 findings in Food Bioscience showed pterostilbene increased fatty acid oxidation and reduced lipid buildup in cultured mouse skeletal muscle cells.
The Japanese team said the berry- and grape-derived polyphenol appeared to preserve PPAR-delta, a protein that regulates fat processing, helping cells break down stored fat.
Researchers screened several food-derived compounds and found pterostilbene produced the strongest drop in fat accumulation without disrupting muscle growth.
Excess fat inside muscle cells can impair glucose and fatty-acid use and contribute to insulin resistance, giving the work relevance to obesity, type 2 diabetes and age-related metabolic decline.
The evidence is still limited to lab-grown mouse cells; outside experts said digestion, absorption and species differences mean the results do not show that eating blueberries or taking supplements reduces human muscle fat.