Restoring Menin Reversed Aging Signs in Mice Within 30 Days as D-serine Boosted Memory
Updated
Updated · ScienceDaily · Oct 12
Restoring Menin Reversed Aging Signs in Mice Within 30 Days as D-serine Boosted Memory
3 articles · Updated · ScienceDaily · Oct 12
Summary
Older mice given hypothalamic Menin restoration showed thicker skin, higher bone mass, better balance and stronger learning and memory within 30 days, pointing to a brain pathway that can reverse several aging markers.
Researchers traced the effect to age-related Menin loss in hypothalamic neurons, which increased inflammation and lowered D-serine by disrupting a serine-production pathway tied to the PHGDH enzyme.
Three weeks of D-serine in drinking water improved learning and memory in older mice even without restoring Menin, but it did not recover bone or skin changes, suggesting Menin acts through broader mechanisms.
Human relevance remains unproven: a 2016 trial in 50 older adults found limited cognitive gains from D-serine, while later studies raised context-dependent effects and kidney-safety questions at high doses.
The findings add to 2024-2026 mouse research linking hypothalamic circuits to metabolism, biological age and lifespan, reinforcing the brain as a potential control center for systemic aging.