Intensive 24-Week Program Drives 54% Type 2 Diabetes Remission in Young Adults

3 articles · Updated · health.yahoo.com · Oct 24

27 of 50 adults ages 18 to 45 in the intervention arm reached type 2 diabetes remission after 24 weeks, versus 2 of 46 in usual care.
The randomized RESET trial used an 800-to-900-calorie medically supervised diet, meal replacements, medication adjustments, and structured aerobic and resistance training rather than standard lifestyle advice.
Participants in the program lost 8.4 kg on average versus 1.2 kg in usual care, while researchers said fat-free mass was preserved and strength and fitness improved.
43 of 50 intervention participants reported at least one adverse event—mostly constipation, headache, dizziness, and fatigue—though no serious adverse events were reported.
The 96-person study applied only to younger adults with obesity, diagnosed within six years and not using insulin; remission meant HbA1c below 6.5% without glucose-lowering drugs, not a cure.