Pantethine Eases Psoriasis in 24-Patient Trial as Vitamin B5 Derivative Calms Immune Cells
Updated
Updated · ScienceDaily · Nov 9
Pantethine Eases Psoriasis in 24-Patient Trial as Vitamin B5 Derivative Calms Immune Cells
2 articles · Updated · ScienceDaily · Nov 9
Summary
A 24-patient trial found psoriasis symptoms improved more after 12 weeks when pantethine tablets were added to standard calcipotriene/betamethasone ointment, with the clearest gains in patients with high cholesterol.
Researchers traced the effect to dendritic cells: excess Vanin enzyme activity depleted pantethine, boosted cholesterol production inside the cells and drove the immune overactivation linked to psoriasis.
In mice, restoring pantethine levels prevented psoriasis from developing, while a Vanin-blocking drug also reduced disease by dampening dendritic-cell activation and T-cell stimulation.
The study positions the vitamin B5 derivative as a potential add-on treatment for psoriasis and possibly other autoimmune diseases, though the authors say larger human studies are needed.