University of Nottingham Develops Fluoride-Free Gel to Regrow Tooth Enamel for Nearly 50% Affected by Dental Disease
Updated
Updated · ScienceDaily · Jul 23
University of Nottingham Develops Fluoride-Free Gel to Regrow Tooth Enamel for Nearly 50% Affected by Dental Disease
3 articles · Updated · ScienceDaily · Jul 23
Summary
University of Nottingham researchers developed a fluoride-free gel that rebuilds damaged tooth enamel by filling microscopic cracks and using calcium and phosphate from saliva to grow a new mineral layer.
Nature Communications published the study, which says the gel mimics proteins involved in enamel formation in infancy and guides crystal growth to align with the tooth’s existing structure.
Lab tests found the regenerated surface behaved like healthy enamel under brushing, chewing and acidic-food exposure, suggesting durability for practical dental use.
The material also formed an enamel-like layer over exposed dentine, potentially reducing tooth sensitivity and improving the bonding surface for fillings and other restorations.
Mintech-Bio, the team’s startup, is pursuing commercialization and aims to launch a first clinical product by next year for erosion treatment, sensitive teeth and related dental applications.
This new gel uses saliva to rebuild teeth. Could it make traditional fluoride treatments obsolete?
As human trials proceed, can this lab-grown enamel survive the harsh environment of a real mouth?
If a gel can truly regrow our teeth, is this the beginning of the end for the dentist's drill?
The Nottingham Enamel Regeneration Gel: Transforming Dental Care Through Clinical Trials and Bioinspired Science
Overview
The Nottingham enamel regeneration gel is now in human clinical trials, which began in early 2026. These trials are a crucial step to confirm that the gel, which showed in the lab that it can regenerate enamel behaving just like healthy enamel under real-life conditions, is safe and effective for patients. Rigorous testing ensures the treatment works as expected in clinical settings. The outcome of these trials is essential, as success could lead to a new era in dental care where lost enamel is rebuilt naturally, moving beyond traditional drilling and filling methods.