Phase 3 Trial Finds 38% SDF Arrests Decay in 830 Children as Drill-Free Option Emerges
Updated
Updated · Medical Daily · Jul 31
Phase 3 Trial Finds 38% SDF Arrests Decay in 830 Children as Drill-Free Option Emerges
3 articles · Updated · Medical Daily · Jul 31
Summary
830 U.S. children under 6 with severe early childhood caries were randomized in a phase 3 trial, which found 38% silver diamine fluoride arrested decay in more than half of affected baby teeth with six-month applications.
SDF is painted onto cavities in seconds and needs no drilling, injections or sedation, making it a potential alternative for preschoolers who might otherwise need fillings under general anesthesia.
The treatment does not replace fillings: it leaves the cavity in place, must be reapplied regularly, and cannot treat abscesses or other active infections.
Its main trade-off is cosmetic — the decayed part of the tooth turns permanently black — a drawback families must weigh against anesthesia risk, long waits and costs that can run into thousands of dollars.
The product has been used off-label in the U.S. since 2014 for cavities after clearance for tooth sensitivity, and researchers say the trial was designed to support FDA approval and broader insurance coverage.