Bailey and her twin Alfie were born in September 2024 after Kindred Companion Sciences switched off dogs’ main allergy-causing gene, and tests found no trace of the target protein in their saliva or fur.
Walker, a geneticist with dog allergies, showed no skin reaction to extracts from the beagles’ saliva and dander, while samples from a poodle and goldendoodle still triggered a response.
The study, published Wednesday in the CRISPR Journal, is described as the first successful use of this approach in dogs, though outside experts said broader human testing is still needed because the edited gene is not the only canine allergen source.
Years of follow-up and commercialization work still lie ahead, with researchers monitoring the pups’ long-term health and bioethicists warning that engineered pets could further sideline shelter and rescue animals.