Tadalafil Linked to 22% Higher Glaucoma Risk Over 5 Years
Updated
Updated · Gizmodo · Aug 19
Tadalafil Linked to 22% Higher Glaucoma Risk Over 5 Years
3 articles · Updated · Gizmodo · Aug 19
Summary
36,927 tadalafil users followed for five years had a 22% higher risk of developing glaucoma than 36,927 matched non-PDE5i users, Taiwanese researchers reported.
The study focused on daily, long-term tadalafil use for lower urinary tract symptoms, a dosing pattern the authors said had lacked clear evidence on glaucoma risk.
Tadalafil users also showed a 32% higher risk of ocular hypertension, adding to prior concerns around PDE5 inhibitors and adverse eye events such as optic neuropathy and maculopathy.
The authors said the findings suggest long-term PDE5 inhibitor use may alter ocular physiology and support closer eye monitoring for patients with glaucoma risk factors.